Leishmanicidal Activity of Withanolides from Aureliana Fasciculata var. Fasciculata
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چکیده
منابع مشابه
In vitro antioxidant and free radical scavenging potential of Cyanotis fasciculata var . fasciculata
Being encouraged by the results of qualitative analysis followed by quantification studies of antioxidants found in various extracts of Cyanotis fasciculata, the present study was designed to assess the free radical scavenging activity of 70% hydro alcoholic (AE) and methanolic extracts (ME) of this plant through DPPH and hydroxyl radical scavenging activities, in addition to ferric reducing as...
متن کاملThe growth and nutrition of Crithidia fasciculata.
The conditions for luxuriant axenic cultivation of the trypanosomid flagellate Crithidia fasciculata in chemically-defined media were determined. Improvements over the hitherto published media include higher concentrations of amino acids, folic acid (where this is the sole source of pteridine) and purines and the inclusion of threonine and Tween 80. Increased oxygenation was obtained by incubat...
متن کاملCharacterization of recombinant glutathionylspermidine synthetase/amidase from Crithidia fasciculata.
Trypanothione [N1,N8-bis(glutathionyl)spermidine] is a unique metabolite found only in trypanosomatids, where it subsumes many of the functions of GSH in other organisms. In Crithidia fasciculata, two distinct ATP-dependent ligases, glutathionylspermidine synthetase (GspS; EC 6.3.1.8) and trypanothione synthetase (TryS; EC 6.3.1.9), are involved in the synthesis of trypanothione from GSH and sp...
متن کاملCharacterization of the respiratory chain from cultured Crithidia fasciculata.
Mitochondrial mRNAs encoding subunits of respiratory-chain complexes in kinetoplastids are post-transcriptionally edited by uridine insertion and deletion. In order to identify the proteins encoded by these mRNAs, we have analyzed respiratory-chain complexes from cultured cells of Crithidia fasciculata with the aid of 2D polyacrylamide gel electrophoresis (PAGE). The subunit composition of F0F1...
متن کاملWithanolides with phytotoxic activity from Jaborosa caulescens var. caulescens and J. caulescens var. bipinnatifida 1.
Seven new withanolides (1-7) were isolated from the aerial parts of Jaborosa caulescens var. caulescens and Jaborosa caulescens var. bipinnatifida. Three of the new compounds are related to jaborosalactones R, S, and T with a delta-lactone side chain and a hemiketal (or ketal) ring formed between a 21-hydroxyl and a 12-ketone (1-3). Compounds 4-7 are trechonolide-type withanolides with a gamma-...
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ژورنال
عنوان ژورنال: Molecules
سال: 2018
ISSN: 1420-3049
DOI: 10.3390/molecules23123160